Variant alert system of VUSKB
The Variant Alert System of VUSKB is an automated monitoring pipeline that continuously compares user-submitted genetic variant classifications with the latest ClinVar updates. By identifying discrepancies between current clinical interpretations and prior classifications, the system enables real-time tracking of variant status changes.*We check the status of user-submitted variants of uncertain significance (VUS) every 24 hours and notify users via email whenever an update is found in the ClinVar database.